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Retinoblastoma protein function

Retinoblastoma protein - Wikipedi

The retinoblastoma protein (protein name abbreviated Rb; gene name abbreviated RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. One function of Rb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide The retinoblastoma protein (RB1) is a critical tumor suppressor gene that blocks cell cycle progression by inhibiting E2F transcription factors when unphosphorylated. On phosphorylation by cyclin-dependent kinases, RB1 is targeted for degradation and the E2F transcription factors are allowed to be active Studies of the retinoblastoma protein and E2F transcription factor have been done to somehow find a treatment for cancer. A compound, β-Lapachone that comes from trees in South America, is currently used as a drug for cancer treatment. It functions to inhibit proliferation of cells by enhancing the binding of the pRb/E2F complex

Retinoblastoma Protein - an overview ScienceDirect Topic

  1. Retinoblastoma proteins are eukaryotic transcriptional corepressors that play central roles in cell cycle control, among other functions. Although most metazoan genomes encode a single retinoblastoma protein, gene duplications have occurred at least twice: in the vertebrate lineage, leading to Rb , p107 , and p130 , and in Drosophila, an ancestral Rbf1 gene and a derived Rbf2 gene
  2. pRB is the protein product of the retinoblastoma tumor suppressor gene, RB1. Its biological functions include controlling the cell cycle, preserving genome integrity, mediating differentiation, as well as protecting cells from apoptosis
  3. The retinoblastoma tumor suppressor protein (Rb) affects gene transcription both negatively and positively and through this regulates distinct cellular responses. Although cell cycle regulation requires gene repression, Rb's ability to promote differentiation and part of its antiproliferative activity appears to rely on the activation of gene transcription
  4. Retinoblastoma (RB) is a tumor suppressor gene which functions as a negative regulator of the cell cycle by interacting with transcription factors including E2F1, PU1, ATF2, UBF, Elf1 and cAbl. RB protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth

The retinoblastoma protein, pRB, was discovered because it suppresses the formation of the rare tumor of the retina, retinoblastoma. However, pRB is also an important transcription factor that controls both cell cycle progression and differentiation Retinoblastomprotein (proteinet förkortat pRb eller Rb, genen förkortad RB eller RB1) är en tumörsuppressor. RB inhiberar transkriptionsfaktorn E2F vars målgener är viktiga vid replikation, detta hindrar dessa proteiner från att uttryckas

Retinoblastoma protein - Proteopedia, life in 3

Diversification of Retinoblastoma Protein Function

  1. The Retinoblastoma Protein: Functions Beyond the G1-S Regulator. Author(s): Chiharu Uchida. Journal Name: Current Drug Targets. Volume 13 , Issue 13 , 2012. DOI: 10.2174/138945012803529938. Journal Home. Abstract: Retinoblastoma protein (pRB) is functionally inactivated in a large.
  2. While the Retinoblastoma protein differs in its function, it acts in a similar manner to typical signal transduction proteins. Here's how it works. The RB1 gene is widely expressed, encoding a 110-kd (4.7 kb) nuclear protein, pRb. Generally speaking, in normal cells pRb is inactivated by phosphorylation and activated by dephosphorylation
  3. The Retinoblastoma Protein: Functions Beyond the G1-S Regulator. Author(s): Chiharu Uchida. Journal Name: Current Drug Targets. Volume 13 , Issue 13 , 2012. DOI: 10.2174/138945012803529938. Journal Home. Abstract: Retinoblastoma protein (pRB) is functionally.
  4. Retinoblastoma Proteins may have Conserved Functions in Germline Development Retinoblastoma Proteins Connect Stem cell Maintenance to cell Proliferation and Differentiation Perturbation of RBR During Leaf Development Affects cell Proliferation and Control of DNA Replicatio
  5. One of the most ancient of regulatory molecules, retinoblastoma (Rb) proteins are evolutionarily conserved transcriptional corepressors and chromatin regulators found in most eukaryotes, from algae and plants to animals
  6. Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest

function of p16 INK4ais to regulate the cell cycle by binding to cyclin-dependent kinases (cdk) 4/6. This prevents the formation of an active cyclin D-cdk4/6 complex. The initial cyclin D-associated phosphor-ylation of the retinoblastoma protein (Rb), funda-mental for cell cycle progress, is therefore inhibite Retinoblastoma is a tumor suppressor gene that plays a very vital role in cell cycle regulation. It works as a negative regulator in cell cycle progression.T.. In yeast and animal systems, retinoblastoma proteins can function as transcriptional repressors by recruiting HD1/RPD3 histone deacetylases (HDACs). Retinoblastoma-associated proteins similar to. Retinoblastoma protein function and p16(INK4a) expression in actinic keratosis, squamous cell carcinoma in situ and invasive squamous cell carcinoma of the skin and links between p16(INK4a) expression and infiltrative behavior. / Nilsson, Kristina; Svensson Månsson, Sofie; Landberg, Göran. In: Modern Pathology, Vol. 17, No. 12, 2004, p. 1464.

The retinoblastoma tumor suppressor protein, RB, contains at least three distinct protein binding domains. The A/B pocket binds proteins with the LXCXE motif, the C pocket binds the nuclear c-Abl tyrosine kinase, and the large A/B pocket binds the transcription factor E2F. Dissociation of RB from its targets is observed as RB becomes phosphorylated during G1/S progression Biochemical analysis of the retinoblastoma protein's function has received considerable attention since it was cloned just over 20 years ago. During this time pRB has emerged as a key regulator of the cell division cycle and its ability to block proliferation is disrupted in the vast majority of human cancers. Much has been learned about the regulation of E2F transcription factors by pRB in. Biological function of the retinoblastoma protein requires distinct domains for hyperphosphorylation and transcription factor binding The Retinoblastoma protein plays an essential function in permanent cell cycle arrest and differentiation of adipocytes [ 14 ], myotubes [ 15 ], osteoblasts [ 16 ], and neurons [ 17 ]. In mechanistic terms, much of pRB's ability to control the cell cycle has been linked to its ability to regulate transcription [ 4, 18 ] Retinoblastoma protein (pRB) controls cell cycle progression and cell cycle exit through interactions with cellular proteins

Retinoblastoma protein - Proteopedia, life in 3D

Retinoblastoma protein (RB) Entry whose protein (s) existence is based on evidence at protein level (2004) Hansen et al. Proceedings of the National Academy of Sciences of the United States of America. Adipocyte precursor cells give raise to two major cell populations with different physiological roles: white and brown adipocytes. Here we demonstrate that the retinoblastoma protein (pRB) regula.. Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation. Proceedings of the National Academy of Science of the United States of America, 101, 4112-4117

Androgen Receptor Tumor Suppressor Function Is Mediated by

Retinoblastoma Protein, Biological and Clinical Functions

Here, we show a novel function for retinoblastoma protein (Rb), where Rb causes sarcomeric disorganization. In human skeletal muscle myotubes (HSMMs), up-regulation of cyclin-dependent kinase 4 (CDK4) and concomitant phosphorylation of Rb was induced by TNF-α treatment, resulting in the translocation of phosphorylated Rb to the cytoplasm The retinoblastoma susceptibility gene (RB) product, the retinoblastoma protein (pRb), functions as a regulator of cell proliferation. Introduction of the RB gene into SAOS-2 osteosarcoma cells, which lack functional pRb, prevents cell cycle progression. Such growth-suppressive functions can be modulated by phosphorylation of pRb, which occurs via. Loss of function of the retinoblastoma gene (RB1) is the rate-limiting step in the initiation of both the hereditary and sporadic forms of retinoblastoma tumor.Furthermore, loss of function of the retinoblastoma tumor suppressor protein (pRB) is frequently found in most human cancers The retinoblastoma tumor suppressor protein (pRB) plays an integral role in G 1-S checkpoint control and consequently is a frequent target for inactivation in cancer. The RB protein can function as an adaptor, nucleating components such as E2Fs and chromatin regulating enzymes into the same complex The retinoblastoma susceptibility gene (RB) product, the retinoblastoma protein (pRb), functions as a regulator of cell proliferation. Introduction of the RB gene into SAOS-2 osteosarcoma cells, which lack functional pRb, prevents cell cycle progression. Such growth-suppressive functions can be modulated by phosphorylation of pRb, which occurs via cell cycle-regulated kinases

The growth suppression function of the retinoblastoma protein (RB) is mediated by its interaction with a variety of cellular proteins The human retinoblastoma (RB1) protein is a tumor suppressor that negatively regulates cell cycle progression through its interaction with members of the E2F/DP family of transcription factors Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiatio The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008 Retinoblastoma 1. RETINOBLASTOMA Dr. Pavan Naik 2. HISTORY First mentioned by Petras Pawius in Amsterdam -1597. James Wardrop- scottish surgeon first recommended enucleation for saving lives - 1809. Verhoeff -origin from undifferentiated retinal cells, named retinoblastoma in 1900's. American Ophthalmology Society first adopted the term retinoblastoma in 1926

Recently, we found that retinoblastoma-associated protein 48 (RbAp48) induces tissue-specific apoptosis in the exocrine glands depending on the level of estrogen deficiency. In this study, we report that transgenic (Tg) expression of RbAp48 resulted in the development of autoimmune exocrinopathy resembling Sjögren's syndrome We explored the function of the retinoblastoma protein (pRb) in aortic valve disease, given its critical role in mesenchymal cell differentiation including bone development and mineralization In higher eukaryotes, a major target of the CDKs is the retinoblastoma (Rb) tumor-suppressor protein that controls progression through G 1 phase of the cell cycle. The pathway controlled by Rb may.. The retinoblastoma protein is mutated or functionally inactivated in nearly all human cancers, Frolov said. The best-known function of pRB is to promote exit from the cell cycle. As normal cells exit cell cycle, they undergo differentiation, a series of events to become specialized cells such as those of skin, bone or muscle The growth suppression function of the retinoblastoma protein (RB) is mediated by its interaction with a variety of cellular proteins. RB contains at least two protein-binding pockets: the large A/B pocket, which interacts with E2F and the D-type cyclins, and the C pocket, which interacts with the nuclear c-Abl tyrosine.

Cell cycle regulation and cancer

The retinoblastoma tumor suppressor protein, RB, contains at least three distinct protein binding domains. The A/B pocket binds proteins with the LXCXE motif, the C pocket binds the nuclear c-Ab1 tyrosine kinase, and the large A/B pocket binds the transcription factor E2F Differentiation resistance through altered retinoblastoma protein function in acute lymphoblastic leukemia: in silico modeling of the deregulations in the G1/S restriction point pathway Eleftherios Ouzounoglou , Dimitra Dionysiou , and Georgios S. Stamatako The major regulator of the gap-1/synthesis phase (G1/S) cell cycle checkpoint is the retinoblastoma protein (pRb), and this is regulated in part by the activities of cyclin-dependent kinase (cdk)-4 and the D cyclins. Surprisingly, given the potential importance of β-cell replication for islet replacement therapy, pRb presence, phosphorylation status, and function have not been explored in β. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity) The RB1 gene provides instructions for making a protein called pRB. This protein acts as a tumor suppressor, which means that it regulates cell growth and keeps cells from dividing too fast or in an uncontrolled way. Under certain conditions, pRB stops other proteins from triggering DNA replication, the process by which DNA makes a copy of itself

Tumor Suppressor Genes

ment of hypophosphorylated retinoblastoma protein (Rb) to AR binding sites and enhanced in PCa cells expressing higher level of AR. Because androgens at intermediate levels can stimulate rather than impair the cell cycle in the LNCaP PCa cell line, we further explored AR regulation of these genes in LNCaP cells In accordance with its tumor suppressor role, the retinoblastoma protein pRb can ensure pro-apoptotic functions. R bf1 , the Drosophila homolog of Rb , also displays a pro-apoptotic activity in proliferative cells. We have previously shown that the R bf1 pro-apoptotic activity depends on its ability to decrease the level of anti-apoptotic proteins such as the Bcl-2 family protein Buffy

Selective ablation of retinoblastoma protein function by

The retinoblastoma protein (Rb), which typically functions as a transcriptional repressor of E2F‐regulated genes, represents a major control hub of the cell cycle. Here, we show that loss of the Arabidopsis Rb homolog RETINOBLASTOMA‐RELATED 1 (RBR1) leads to cell death, especially upon exposure to genotoxic drugs such as the environmental toxin aluminum The RETINOBLASTOMA-RELATED (RBR) protein cell-autonomously reinforces mitotic quiescence in the QC. RBR interacts with the stem cell transcription factor SCARECROW (SCR) through an LxCxE motif. Disruption of this interaction by point mutation in SCR or RBR promotes asymmetric divisions in the QC that renew short-term stem cells

RB (Retinoblastoma Protein) NeoGenomics Laboratorie

  1. The retinoblastoma tumor suppressor protein (pRb) regulates the cell cycle, facilitates differentiation, and restrains apoptosis. Furthermore, dysfunctional pRb is thought to be involved in the development of most human malignancies. Many of the functions of pRb are mediated by its regulation of the E2F transcription factors
  2. Saijo et al. (1995) found that the RBBP5 protein preferentially binds to underphosphorylated RB protein. The region used for binding to this protein was mapped to the E1A-binding pocket B of pRB, which has sequence similarity to the general transcription factor TFIIB ().RBBP5 is a component of the mammalian SET1A ()/SET1B histone H3-Lys4 methyltransferase complexes (Lee et al., 2007)
  3. Das Retinoblastom-Protein (pRb, Rb) ist ein Tumorsuppressor-Protein, das bei vielen Tumoren eine gestörte Funktion besitzt. Eine sehr gut untersuchte Funktion von pRb ist es, das Zellwachstum zu verlangsamen, indem der Durchlauf des Zellzyklus gebremst wird. pRb gehört zu der sogenannten Pocket-Protein-Familie.Deren Mitglieder besitzen für die Bindung an andere Proteine eine molekulare Tasche
  4. Retinoblastoma is a rare type of eye cancer that usually develops in early childhood, typically before the age of 5. This form of cancer develops in the retina, which is the specialized light-sensitive tissue at the back of the eye that detects light and color.In children with retinoblastoma, the disease often affects only one eye. Explore symptoms, inheritance, genetics of this condition
  5. al Cell Cycle Arrest Associated with Myogenesis* The acquisition of skeletal muscle-specific function and ter
Mini review: Multifaceted role played by cyclin D1 in

Retinoblastoma Protein, biological and clinical functions

  1. The retinoblastoma protein (pRb) is a tumor suppressor that is deleted, mutated, or inactivated in most lung cancer cases. Canonically, pRb functions to regulate cell cycle progression by repressing the transcriptional activity of the E2F family of transcription factors, inhibiting S phase entry
  2. Retinoblastoma protein function and p16(INK4a) expression in actinic keratosis, squamous cell carcinoma in situ and invasive squamous cell carcinoma of the skin and links between p16(INK4a) expression and infiltrative behavior. Research output: Contribution to journal › Article
  3. The biological function of the retinoblastoma protein (RB) in the cell division cycle has been extensively documented, but its apparent role in differentiation remains largely unexplored. To investigate how RB is involved in differentiation, the U937 large-cell lymphoma line was induced to differentiate along a monocyte/macrophage lineage
  4. us of RB1. By screening a HeLa cell cDNA library with a PCR product that was generated using oligonucleotides.

T1 - Expression and function of retinoblastoma binding protein 6 (RBBP6) in human lung cancer. AU - Motadi, L.R. AU - Bhoola, Kanti. AU - Dlamini, Z. PY - 2011. Y1 - 2011. N2 - Retinoblastoma binding protein 6 (RBBP6) interacts with both p53 and pRb, and has been identified as an E3 ubiquitin ligase due to the presence of a RING finger domain Retinoblastoma Protein in Drosophila Du, Wei University of Chicago, Chicago, IL, United States. Search 48 grants from Wei Du Search grants from University of Chicago. Share this grant: : : Abstract; Funding; Institution; Related projects; Publications; Comments; Recent in Grantomics: University of. The retinoblastoma protein is phosphorylated on multiple sites by human cdc2. Lees JA, Buchkovich KJ, Marshak DR, Anderson CW, Harlow E: The EMBO journal. 1991 ; 10 (13) : 4279-4290. PMID 1756735 : Genomic organization of the human retinoblastoma gene. T'Ang A, Wu KJ, Hashimoto T, Liu WY, Takahashi R, Shi XH, Mihara K, Zhang FH, Chen YY, Du

Retinoblastomprotein - Wikipedi

  1. function of the retinoblastoma tumor suppressor protein (pRB) is frequently found in most human cancers. In retinoblastoma, tumor progression is driven by epigenetic changes following pRB loss. This review focuses on the diverse functions of pRB in epigenetic regulation
  2. Loss of function of RB1 gene in sporadic retinoblastoma could result from the mutations of both RB1 alleles, or with the loss of heterozygosity (LOH; Choy et al., 2002). In human embryonic stem cells, knocking out RB1 gene by CRISPR/Cas9 would lead to the formation of neural enriched teratomas, which mimic the trilateral retinoblastoma tumors ( Avior et al., 2017 )
  3. The retinoblastoma protein: a master tumor suppressor acts as a link between cell cycle and cell adhesion Brienne E Engel,1 W Douglas Cress,1 Pedro G Santiago-Cardona2 1Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; 2Department of Biochemistry, Ponce School of Medicine, Ponce, Puerto Rico, USA Abstract: RB1 was the first tumor suppressor gene discovered
  4. Loss of function of the retinoblastoma gene ( RB1) is the rate-limiting step in the initiation of both the hereditary and sporadic forms of retinoblastoma tumor. Furthermore, loss of function of the retinoblastoma tumor suppressor protein (pRB) is frequently found in most human cancers. In retinoblastoma, tumor progression is driven by epigenetic.
  5. Retinoblastoma protein (Rb) prevents tumor formation by inducing differentiation, controlling cell-cycle progression, and maintaining genomic stability (Burkhart and Sage, 2008). To date, numerous studies of Rb function have focused on the transcriptional regulation of E2F
  6. Function of the Retinoblastoma Protein Harlow, Edward E. Massachusetts General Hospital, Boston, MA, United States. Search 68 grants from Edward Harlow Search grants from Massachusetts General Hospital. Share this grant: : : Abstract; Funding; Institution; Related projects.

RB and cell cycle progressio

Entrez GeneNuclear lamina

A-type lamins regulate retinoblastoma protein function by

Retinoblastoma protein and Knudson hypothesis · See more » LIN9. Lin-9 homolog is a protein that is encoded by the LIN9 gene in humans. New!!: Retinoblastoma protein and LIN9 · See more » Linear function. In mathematics, the term linear function refers to two distinct but related notions. New!!: Retinoblastoma protein and Linear function. The retinoblastoma tumor suppressor protein, RB, contains at least three distinct protein binding domains. The A/B pocket binds proteins with the LXCXE motif, the C pocket binds the nuclear c-Abl tyrosine kinase, and the large A/B pocket binds the transcription factor E2F

Functions of the retinoblastoma protein - Kaelin - 1999

Retinoblastoma is a human childhood disease, involving a tumor of the retina. It occurs both as a heritable trait and sporadically (by somatic mutation). It is often associated with deletions of band q 14 of human chromosome 13. The RB gene has been localized to this region by molecular cloning. Summarizes the situation. Retinoblastoma and E2F Protein. Read More The role of retinoblastoma protein in apoptosis The role of retinoblastoma protein in apoptosis Fan, G.; Steer, C. 2004-09-30 00:00:00 The retinoblastoma gene and its protein product (Rb) have been studied intensively for their role in development, oncogenesis, cell growth, differentiation and cell cycle regulation. In addition, Rb appears to be a key factor in protecting cells from apoptosis Saijo et al. (1995) found that the RBBP5 protein preferentially binds to underphosphorylated RB protein. The region used for binding to this protein was mapped to the E1A-binding pocket B of pRB, which has sequence similarity to the general transcription factor TFIIB ( 189963 ). RBBP5 is a component of the mammalian SET1A ( 611052 )/SET1B ( 611055). A plausible hypothesis documented in literature suggests that this cell cycle related behavior could be the consequence of a partial inactivation of retinoblastoma protein functions, especially those concerning the differentiation program of the cell

Estrogens and atherosclerosis: insights from animal modelsRETINOBLASTOMA-RELATED Protein Stimulates Cell

The retinoblastoma family of proteins and their regulatory

Retinoblastoma is a rare type of eye cancer that usually develops in early childhood, typically before the age of 5. This form of cancer develops in the retina, which is the specialized light-sensitive tissue at the back of the eye that detects light and color.In children with retinoblastoma, the disease often affects only one eye The retinoblastoma (RB) protein family in mammals is composed of three members: pRB (or RB1), p107, and p130. Although these proteins do not directly bind DNA, they associate with the E2F family of transcription factors which function as DNA sequence-specific transcription factors The retinoblastoma susceptibility gene (RB) product, the retinoblastoma protein (pRb), functions as a regulator of cell proliferation. Introduction of the RB gene into SAOS-2 osteosarcoma cells, which lack functional pRb, prevents cell cycle progression The retinoblastoma gene was identified over a decade ago as the first tumor suppressor. Although the gene was initially cloned as a result of its frequent mutation in the rare pediatric eye tumor, retinoblastoma (Friend et al. 1986; Fung et al. 1987; Lee et al. 1987), it is now thought to play a fundamental role in cellular regulation and is the target of tumorigenic mutations in many cell types

↑ Vorobiev SM, Huang YJ, Seetharaman J, Xiao R, Acton TB, Montelione GT, Tong L. Human retinoblastoma binding protein 9, a serine hydrolase implicated in pancreatic cancers. Protein Pept Lett. 2012 Feb;19(2):194-7. PMID:2193311 Harbour, JW & Dean, DC 2000, ' Corepressors and retinoblastoma protein function ', Current topics in microbiology and immunology, vol. 254, pp. 137-144 Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene. RBL2. Available structures. PDB. Ortholog search: PDBe RCSB. List of PDB id codes. 4XI9, 5C1D. Identifiers It is a binding partner of the retinoblastoma protein, a central player in regulation of the cell cycle, differentiation of cells, and programmed cell death. Retinoblastoma protein was the first oncogene to be discovered, and mutations in the protein are often found in cancer cells, allowing them to evade the normal controls on growth

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